drug discovery

Kemotech

Kemotech

 

Small molecule
Sintesi chimica

Pubblicazioni KemoTech srl

  1. G.Loriga, P.Lazzari, I.Manca, S.Ruiu, M.Falzoi, G.Murineddu, M.E.H.Bottazzi, G.Pinna, G.A.Pinna. Novel diazabycycloalkane delta opioid agonists. Bioorg.Med.Chem., 23 (2015) 5527-5538.
  2. O.F.Lamidi, M.Sani, P.Lazzari, M.Zanda, I.N.Fleming. The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2. J.Cancer Res.Clinic.Oncol., 2015; DOI 10.1007/s00432-015-1921-6.
  3. C.Zanato, M.G.Cascio, P.Lazzari, R.Pertwee, A.Testa, M.Zanda. Tricyclic fused pyrazoles with a “click” 1,2,3-triazole substituent in position 3 are nanomolar CB1 receptor ligands. Synthesis, 47 (2015) 817-826.
  4. R.Cohen, D.J.Vugts, G.W.M.Visser, M.Stigter-Van Walsum, M.Bolijn, M.Spiga, P.Lazzari, S.Shankar, M.Sani, M.Zanda, G.A.M.S.Van Dongen. Development of novel ADCs: Conjugation of tubulysin analogs to Trastuzumab monitored by dual radiolabeling. Cancer Research, 74 (2014) 5700-5710.
  5. G.Pinna, M.M.Curzu, A.Dore, P.Lazzari, S.Ruiu, A.Pau, G.Murineddu, G.A.Pinna. Tricyclic pyrazoles Part 7. Discovery of potent and selective dihydrothienocyclopentapyrazole derived CB2 ligands. Eur. J. Med. Chem., 85 (2014) 747-757.
  6. G.Pinna, G.Loriga, P.Lazzari, S.Ruiu, M.Falzoi, S.Frau, A.Pau, G.Murineddu, B.Asproni, G.A.Pinna. Tryciclic pyrazoles. Part 6. Benzofuro[3,2-c]pyrazole: a versatile architecture for CB2 selective ligands. Eur. J. Med. Chem., 82 (2014) 281-292.
  7. S.Tambaro, M.A.Casu, A.Mastinu, P.Lazzari. Evaluation of selective cannabinoid CB1 and CB2 receptor agonists in a mouse model of lipopolysaccharide-induced interstitial cystitis. Eur. J. Pharmacol., 79 (2014) 67-74.
  8. R.Distinto, C.Zanato, S.Montanari, M.G.Cascio, P.Lazzari, R.Pertwee, M.Zanda. Pyrazoles with a “click” 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands. Journal of Fluorine Chemistry, 167 (2014) 184-191.
  9. S.Perrone, M.Usai, P.Lazzari, S.J.Tucker, H.M.Wallace. M.Zanda. Efficient cell transfection with melamine-based Gemini surfactants. Biocon. Chem., 24 (2013) 176-187.
  10. P.Fadda, M.Monduzzi, F.Caboi, P.Lazzari. Solid lipid nanoparticle preparation by a warm microemulsion based process: influence of microemulsion microstructure. Int. J. Pharmac., 446 (2013) 166-175.
  11. S.Shankar, S.Bigotti, P.Lazzari, I.Manca, M.Spiga, M.Sani, M.Zanda. Synthesis and cytotoxicity evaluation of diastereoisomers and N-terminal analogues of Tubulysin-U. Tetrahedron Letters, 54 (2013) 6137-6141.
  12. S.Tambaro, R.Reali, A.Volonterio, M.Zanda, F.Olimpieri, G.A.Pinna, P.Lazzari. NESS002ie: a new fluorinated thiol endopeptidase inhibitor with antinociceptive activity in an animal model of persistent pain. Pharmacology, Biochemistry and Behavior, 110 (2013) 137-144.
  13. I.Manca, A.Mastinu, F.Olimpieri, M.Falzoi, M.Sani, S.Ruiu, G.Loroga, A.Volonterio, S.Tambaro, M.E.H.Bottazzi, M.Zanda, G.A.Pinna, P.Lazzari. Novel pyrazole derivatives as neutral CB1 antagonists with significant activity towards food intake. Eur. J. Med. Chem., 62 (2013) 256-269.
  14. S.Shankar, M.Jagodzinska, M.Sani, L.Malpezzi, P.Lazzari, I.Manca, I.R.Greig, M.Zanda. Synthesis and cytotoxicity evaluation of diastereoisomers and N-terminal analogues of Tubulysin-U Organic and Biomolecular Chemistry, 11 (2013) 2273-2287.
  15. A.F.Haag, B.Kerscher, S.Dall’Angelo, M.Sani, R.Longhi, M.Baloban, H.M.Wilson, P.Mergaert, M.Zanda, G.P.Ferguson. Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide Journal of Biological Chemistry, 287 (2012) 10791-10798.
  16. A.F.Haag, M.Baloban, M.Sani, B.Kerscher, O.Pierre, A.Farkas, R.Longhi, E.Boncompagni, D.Hérouart, S.Dall’Angelo, E.Kondorosi, M.Zanda, P.Mergaert, G.P.Fergusson. Protection of Sinorhizobium against host cysteine-rich antimicrobial peptides is critical for symbiosis PLoS Biology, 9: e10001169.
  17. R.Sinisi, A.Ghilardi, S.Ruiu, P.Lazzari, L.Malpezzi, M.Sani, L.Pani, M.Zanda. Synthesis and in vitro evaluation of trifluoroethylamine analogues of enkephalines ChemMedChem, 4 (2009) 1416-1420
  18. G.Candiani, M.Frigerio, F.Viani, C.Verpelli, C.Sala, L.Chiamenti, N.Zaffaroni, M.Folini, M.Sani, W.Panzeri, M.Zanda. Dimerizable redox-sensitive triazine-based cationic lipids for in vitro gene delivery ChemMedChem, 2 (2007) 292-296.
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Attività di ricerca

L’attività di ricerca e sviluppo in proprio di KemoTech è focalizzata principalmente verso lo sviluppo di nuovi composti per l’oncologia ...

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Pubblicazioni

Le competenze tecnico scientifiche e manageriali del Team di KemoTech sono evidenziate dalle oltre 200 pubblicazioni scientifiche su riviste internazionali ...

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Brevetti

Le competenze tecnico scientifiche e manageriali del Team di KemoTech sono evidenziate da più di 30 brevetti internazionali ...

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Kemotech s.r.l.

c/o Parco Scientifico della Sardegna

Ed. 3 - Loc. Piscinamanna

09010 Pula (CA) - Italia

P.I.: IT03042830921

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